“In many studies, DMT has shown to be a promising and effective psychedelic for the treatment of mental health issues. However, known side effects like disorientation and anxiety and its mode of administration have historically hindered its use and availability. CYB004 via inhalation may solve these challenges and finally support a clinical path forward for this important therapeutic. As part of Cybin’s overall mission to create safe and effective psychedelic-based therapeutics, inhaled CYB004 is being developed to potentially overcome the limitations of IV DMT and become an important treatment option for anxiety disorders for patients and physicians,” said Doug Drysdale, Chief Executive Officer of Cybin.
Based on preclinical results, inhaled CYB004 demonstrated:
- Approximately 2000% improved bioavailability compared with orally administered DMT, which is known to have limited to no oral bioavailability
- Approximately 41% improved bioavailability compared with inhaled DMT
- Approximately 300% longer duration of effect when compared with IV DMT, indicating potential to extend therapeutic window
- Rapid onset of effect and similar low variability equivalent to IV DMT